The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

Hoffmann, Markus; Kleine‐Weber, Hannah; Krüger, Nadine; A. Müller, Marcel; Drosten, Christian; Pöhlmann, Stefan

doi:10.1101/2020.01.31.929042

Public

The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

Published in bioRxiv (Cold Spring Harbor Laboratory) • Jan 31, 2020

Authors:

Markus Hoffmann

Hannah Kleine‐Weber

Nadine Krüger

Abstract

Abstract The emergence of a novel, highly pathogenic coronavirus, 2019-nCoV, in China, and its rapid national and international spread pose a global health emergency. Coronaviruses use their spike proteins to select and enter target cells and insights into nCoV-2019 spike (S)-driven entry might faci...

Subject

Coronavirus

TMPRSS2

Virology

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