Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice

P. Méndez-González, Miguel; E. Rivera-Aponte, David; Benedikt, Jan; Maldonado-Martínez, Gerónimo; A. Tejeda-Bayron, Flavia; N. Skatchkov, Serguei; J. Eaton, Misty

doi:10.3390/brainsci10020072

Public

Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice

Published in Brain Sciences • Jan 30, 2020

Authors:

Miguel P. Méndez-González

David E. Rivera-Aponte

Jan Benedikt

Abstract

Epilepsy, characterized by recurrent seizures, affects 1% of the general population. Interestingly, 25% of diabetics develop seizures with a yet unknown mechanism. Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured astrocytes. Therefore, the present study aims...

Subject

Hippocampal formation

Downregulation and upregulation

Potassium channel

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