Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients.

A, Algazi; S, Bhatia; S, Agarwala; M, Molina; K, Lewis; M, Faries; L, Fong; LP, Levine; M, Franco; A, Oglesby; C, Ballesteros-Merino; CB, Bifulco; BA, Fox; D, Bannavong; R, Talia; E, Browning; MH, Le; RH, Pierce; S, Gargosky; KK, Tsai; C, Twitty; AI, Daud

doi:10.1016/j.annonc.2019.12.008

Public

Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients.

Shared by NobleBlocks on Feb 1, 2020 • 12:00 AM UTC

Authors:

Algazi A

Bhatia S

Agarwala S

Abstract

Background Interleukin 12 (IL-12) is a pivotal regulator of innate and adaptive immunity. We conducted a prospective open-label, phase II clinical trial of electroporated plasmid IL-12 in advanced melanoma patients (NCT01502293).Patients and methods Patients with stage III/IV melanoma were treated i...

Subject

Melanoma

Cytokine

Electroporation

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