The lncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/β-Catenin Signaling Pathway

Chen, Zhaolin; Pan, Tingting; Jiang, Duochen; Jin, Le; Geng, Yadi; Feng, Xiaojun; Shen, Aizong; Zhang, Lei

doi:10.1016/j.omtn.2020.01.030

Public

The lncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/β-Catenin Signaling Pathway

Published in Molecular Therapy — Nucleic Acids • Feb 1, 2020

Authors:

Zhaolin Chen

Tingting Pan

Duochen Jiang

Abstract

Drug resistance, including adriamycin (ADR)-based therapeutic resistance, is a crucial cause of chemotherapy failure in breast cancer treatment. Acquired chemoresistance has been identified to be closely associated with the overexpression of P-glycoprotein (P-gp/ABCB1). Long non-coding RNA (lncRNA) ...

Subject

Wnt signaling pathway

Catenin

Cancer research

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