B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

Amcaoglu Rieder, Sadiye; Wang, Jingya; White, Natalie; N. Qadri, Ariful; Ménard, Catherine; L. Stephens, Geoffrey; L. Karnell, Jodi; E. Rudd, Christopher; Kolbeck, Roland

doi:10.1038/s41423-020-0361-7

Public

B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

Published in Cellular and Molecular Immunology • Jan 31, 2020

Authors:

Sadiye Amcaoglu Rieder

Jingya Wang

Natalie White

Abstract

Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases. Therefore, understanding how different receptors on T cells impact functional outcomes is crucial. The influence of B7-H7 (HHLA2) and CD28H (TMIGD2) on T-cell activation remains controversial. Here we e...

Subject

CD28

T-cell receptor

T cell

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