Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial

the Saudi Critical Care Trials group, and; M. Arabi, Yaseen; Y. Asiri, Ayed; M. Assiri, Abdullah; Jokhdar, Hani; Alothman, Adel; H. Balkhy, Hanan; Aljohani, Sameera; Al Harbi, Shmeylan; Kojan, Suleiman; Al Jeraisy, Majed; Deeb, Ahmad; A. Memish, Ziad; Ghazal, Sameeh; Al Faraj, Sarah; Al-Hameed, Fahad; Alsaedi, Asim; Mandourah, Yasser; A. Al Mekhlafi, Ghaleb; Murad Sherbeeni, Nisreen; Elzein, Fatehi; Almotairi, Abdullah; Al Bshabshe, Ali; Kharaba, Ayman; Jose, Jesna; Al Harthy, Abdulrahman; Al Sulaiman, Mohammed; Mady, Ahmed; Fowler, Robert; G. Hayden, Frederick; Al‐Dawood, Abdulaziz; A. Abdelzaher, M.; Bajhmom, Wail; Hussein, Mohamed

doi:10.1186/s13063-019-3846-x

Public

Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial

Published in Trials • Jan 3, 2020

Authors:

and the Saudi Critical Care Trials group

Yaseen M. Arabi

Ayed Y. Asiri

Abstract

The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supp...

Subject

Lopinavir

Medicine

Randomized controlled trial

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