Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Papadimitriou, Nikos; Dimou, Niki; K. Tsilidis, Konstantinos; L. Banbury, Barbara; M. Martin, Richard; J. Lewis, Sarah; Kazmi, Nabila; Robinson, Tim; Albanes, Demetrius; Aleksandrova, Krasimira; I. Berndt, Sonja; Timothy Bishop, D.; Brenner, Hermann; D. Buchanan, Daniel; Bueno‐de‐Mesquita, Bas; T. Campbell, Peter; Castellvı́-Bel, Sergi; T. Chan, Andrew; Chang‐Claude, Jenny; Ellingjord‐Dale, Merete; C. Figueiredo, Jane; Gallinger, Steven; G. Giles, Graham; L. Giovannucci, Edward; B. Gruber, Stephen; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia; A. Harrison, Tabitha; Hoffmeister, Michael; L. Hopper, John; Hsu, Li; María Huerta, José; R. Huyghe, Jeroen; A. Jenkins, Mark; O. Keku, Temitope; Kühn, Tilman; La Vecchia, Carlo; Le Marchand, Loı̈c; I. Li, Christopher; Li, Li; Lindblom, Annika; M. Lindor, Noralane; M. Lynch, Brigid; D. Markowitz, Sanford; Masala, Giovanna; M. May, Anne; L. Milne, Roger; M. Monninkhof, Evelyn; Moreno, Lorena; Moreno, Vı́ctor; A. Newcomb, Polly; Offit, Kenneth; Perduca, Vittorio; D.P. Pharoah, Paul; A. Platz, Elizabeth; D. Potter, John; Rennert, Gad; Ríboli, Elio; Sánchez, María‐José; L. Schmit, Stephanie; E. Schoen, Robert; Severi, Gianluca; Sieri, Sabina; L. Slattery, Martha; Song, Mingyang; M. Tangen, Catherine; N. Thibodeau, Stephen; C. Travis, Ruth; Trichopoulou, Antonia; M. Ulrich, Cornelia; J. B. van Duijnhoven, Franzel; Van Guelpen, Bethany; Vodička, Pavel; White, Emily; Wolk, Alicja; O. Woods, Michael; H. Wu, Anna; Peters, Ulrike; J. Gunter, Marc; Murphy, Neil

doi:10.1038/s41467-020-14389-8

Public

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Published in Nature Communications • Jan 30, 2020

Authors:

Nikos Papadimitriou

Niki Dimou

Konstantinos K. Tsilidis

Abstract

Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA co...

Subject

Breast cancer

Medicine

Colorectal cancer

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