Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma

Fröhlich, Anne; Loick, Sophia; Bawden, Emma; Fietz, Simon; Dietrich, Jörn; Diekmann, Eric; Saavedra, Gonzalo; Fröhlich, Holger; Niebel, Dennis; Sirokay, Judith; Zarbl, Romina; H. Gielen, Gerrit; Kristiansen, Glen; Bootz, Friedrich; Landsberg, Jennifer; Dietrich, Dimo

doi:10.1016/j.ebiom.2020.102647

Public

Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma

Published in EBioMedicine • Feb 1, 2020

Authors:

Anne Fröhlich

Sophia Loick

Emma Bawden

Abstract

BACKGROUND: Immunotherapy, including checkpoint inhibition, has remarkably improved prognosis in advanced melanoma. Despite this success, acquired resistance is still a major challenge. The T cell costimulatory receptor TNFRSF9 (also known as 4-1BB and CD137) is a promising new target for immunother...

Subject

DNA methylation

Immunotherapy

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