Integrative pathway enrichment analysis of multivariate omics data

Paczkowska, Marta; Barenboim, Jonathan; Sintupisut, Nardnisa; S. Fox, Natalie; Zhu, Helen; Abd-Rabbo, Diala; W. Mee, Miles; C. Boutros, Paul; Drivers and Functional Interpretation Working Group, PCAWG; Abascal, Federico; B. Amin, Samirkumar; D. Bader, Gary; Beroukhim, Rameen; Bertl, Johanna; A. Boroevich, Keith; Brunak, Søren; J. Campbell, Peter; Carlevaro-Fita, Joana; Chakravarty, Dimple; Wing Yiu Chan, Calvin; Chen, Ken; Kyoon Choi, Jung; Deu-Pons, Jordi; Dhingra, Priyanka; Diamanti, Klev; Feuerbach, Lars; Lynn Fink, J.; A. Fonseca, Nuno; Frigola, Joan; Gambacorti-Passerini, Carlo; W. Garsed, Dale; Gerstein, Mark; Getz, Gad; Gonzalez-Perez, Abel; Guo, Qianyun; G. Gut, Ivo; Haan, David; P. Hamilton, Mark; J. Haradhvala, Nicholas; O. Harmanci, Arif; Helmy, Mohamed; Herrmann, Carl; M. Hess, Julian; Hobolth, Asger; Hodzic, Ermin; Hong, Chen; Hornshøj, Henrik; Isaev, Keren; M. G. Izarzugaza, Jose; Johnson, Rory; A. Johnson, Todd; Juul, Malene; Istrup Juul, Randi; Kahles, Andre; Kahraman, Abdullah; Kellis, Manolis; Khurana, Ekta; Kim, Jaegil; K. Kim, Jong; Kim, Youngwook; Komorowski, Jan; O. Korbel, Jan; Kumar, Sushant; Lanzós, Andrés; S. Lawrence, Michael; Lee, Donghoon; Lehmann, Kjong-Van; Li, Shantao; Li, Xiaotong; Lin, Ziao; Minwei Liu, Eric; Lochovsky, Lucas; Lou, Shaoke; Madsen, Tobias; Marchal, Kathleen; Martincorena, Iñigo; Martinez-Fundichely, Alexander; E. Maruvka, Yosef; D. McGillivray, Patrick; Meyerson, William; Muiños, Ferran; Mularoni, Loris; Nakagawa, Hidewaki; Muhlig Nielsen, Morten; Park, Keunchil; Park, Kiejung; Skou Pedersen, Jakob; Pich, Oriol; Pons, Tirso; Pulido-Tamayo, Sergio; J. Raphael, Benjamin; Reyes-Salazar, Iker; A. Reyna, Matthew; Rheinbay, Esther; A. Rubin, Mark; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Cenk Sahinalp, S.; Saksena, Gordon; Salichos, Leonidas; Sander, Chris; E. Schumacher, Steven; Shackleton, Mark; Shapira, Ofer; Shen, Ciyue; Shrestha, Raunak; Shuai, Shimin; Sidiropoulos, Nikos; Sieverling, Lina; Sinnott-Armstrong, Nasa; D. Stein, Lincoln; M. Stuart, Joshua; Tamborero, David; Tiao, Grace; Tsunoda, Tatsuhiko; M. Umer, Husen; Uusküla-Reimand, Liis; Valencia, Alfonso; Vazquez, Miguel; P. C. Verbeke, Lieven; Wadelius, Claes; Wadi, Lina; Wang, Jiayin; Warrell, Jonathan; M. Waszak, Sebastian; Weischenfeldt, Joachim; A. Wheeler, David; Wu, Guanming; Yu, Jun; Zhang, Jing; Zhang, Xuanping; Zhang, Yan; Zhao, Zhongming; Zou, Lihua; von Mering, Christian; Reimand, Jüri; Consortium, PCAWG; A. Aaltonen, Lauri; Abascal, Federico; Abeshouse, Adam; Aburatani, Hiroyuki; J. Adams, David; Agrawal, Nishant; Soo Ahn, Keun; Ahn, Sung-Min; Aikata, Hiroshi; Akbani, Rehan; C. Akdemir, Kadir; Al-Ahmadie, Hikmat; T. Al-Sedairy, Sultan; Al-Shahrour, Fatima; Alawi, Malik; Albert, Monique; Aldape, Kenneth; B. Alexandrov, Ludmil; Ally, Adrian; Alsop, Kathryn; G. Alvarez, Eva; Amary, Fernanda; B. Amin, Samirkumar; Aminou, Brice; Ammerpohl, Ole; J. Anderson, Matthew; Ang, Yeng; Antonello, Davide; Anur, Pavana; Aparicio, Samuel; L. Appelbaum, Elizabeth; Arai, Yasuhito; Aretz, Axel; Arihiro, Koji; Ariizumi, Shun-ichi; Armenia, Joshua; Arnould, Laurent; Asa, Sylvia; Assenov, Yassen; Atwal, Gurnit; Aukema, Sietse; Todd Auman, J.; R. R. Aure, Miriam; Awadalla, Philip; Aymerich, Marta; D. Bader, Gary; Baez-Ortega, Adrian; H. Bailey, Matthew; J. Bailey, Peter; Balasundaram, Miruna; Balu, Saianand; Bandopadhayay, Pratiti; E. Banks, Rosamonde; Barbi, Stefano; P. Barbour, Andrew; Barenboim, Jonathan; Barnholtz-Sloan, Jill; Barr, Hugh; Barrera, Elisabet; Bartlett, John; Bartolome, Javier; Bassi, Claudio; F. Bathe, Oliver

doi:10.1038/s41467-019-13983-9

Public

Integrative pathway enrichment analysis of multivariate omics data

Shared by NobleBlocks on Feb 5, 2020 • 12:00 AM UTC

Authors:

Marta Paczkowska

Jonathan Barenboim

Nardnisa Sintupisut

Abstract

Abstract Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across...

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