METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Zhao, Wei; Cui, Yameng; Liu, Lina; Ma, Xiaozhou; Qi, Xiaoqian; Wang, Yue; Liu, Zihao; Ma, Shiqing; Liu, Jingwen; Wu, Jie

doi:10.1016/j.omtn.2020.01.033

Public

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Published in Molecular Therapy — Nucleic Acids • Feb 4, 2020

Authors:

Wei Zhao

Yameng Cui

Lina Liu

Abstract

N 6 -Methyladenosine (m 6 A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N 6 nitrogen of adenosine. However, the roles of m 6 A in oral squamous cell carcinoma (OSCC) are still elusive. Here, we investigate the function and mechanism of methyltran...

Subject

Carcinogenesis

N6-Methyladenosine

Gene knockdown

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