Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Rheinbay, Esther; Muhlig Nielsen, Morten; Abascal, Federico; A. Wala, Jeremiah; Shapira, Ofer; Tiao, Grace; Hornshøj, Henrik; M. Hess, Julian; Istrup Juul, Randi; Lin, Ziao; Feuerbach, Lars; Sabarinathan, Radhakrishnan; Madsen, Tobias; Kim, Jaegil; Mularoni, Loris; Shuai, Shimin; Lanzós, Andrés; Herrmann, Carl; E. Maruvka, Yosef; Shen, Ciyue; B. Amin, Samirkumar; Bandopadhayay, Pratiti; Bertl, Johanna; A. Boroevich, Keith; Busanovich, John; Carlevaro-Fita, Joana; Chakravarty, Dimple; Wing Yiu Chan, Calvin; Craft, David; Dhingra, Priyanka; Diamanti, Klev; A. Fonseca, Nuno; González-Pérez, Abel; Guo, Qianyun; P. Hamilton, Mark; J. Haradhvala, Nicholas; Chen, Hong; Isaev, Keren; A. Johnson, Todd; Juul, Malene; Kahles, André; Kahraman, Abdullah; Kim, Young-Wook; Komorowski, Jan; Kumar, Kiran; Kumar, Sushant; Lee, Donghoon; Lehmann, Kjong-Van; Li, Yilong; Minwei Liu, Eric; Lochovsky, Lucas; Park, Keunchil; Pich, Oriol; D. Roberts, Nicola; Saksena, Gordon; E. Schumacher, Steven; Sidiropoulos, Nikos; Sieverling, Lina; Sinnott-Armstrong, Nasa; Stewart, Chip; Tamborero, David; M. C. Tubío, José; M. Umer, Husen; Uusküla-Reimand, Liis; Wadelius, Claes; Wadi, Lina; Yao, Xiaotong; Zhang, Cheng‐Zhong; Zhang, Jing; E. Haber, James; Hobolth, Asger; Imieliński, Marcin; Kellis, Manolis; S. Lawrence, Michael; von Mering, Christian; Nakagawa, Hidewaki; J. Raphael, Benjamin; A. Rubin, Mark; Sander, Chris; D. Stein, Lincoln; M. Stuart, Joshua; Tsunoda, Tatsuhiko; A. Wheeler, David; Johnson, Rory; Reimand, Jüri; Gerstein, Mark; Khurana, Ekta; J. Campbell, Peter; López-Bigas, Núria; Drivers and Functional Interpretation Working Group, PCAWG; Abascal, Federico; B. Amin, Samirkumar; D. Bader, Gary; Bandopadhayay, Pratiti; Barenboim, Jonathan; Beroukhim, Rameen; Bertl, Johanna; A. Boroevich, Keith; Brunak, Søren; J. 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Umer, Husen; Uusküla-Reimand, Liis; Valencia, Alfonso; Vazquez, Miguel; P. C. Verbeke, Lieven; Wadelius, Claes; Wadi, Lina; Wang, Jiayin; Warrell, Jonathan; M. Waszak, Sebastian; Weischenfeldt, Joachim; A. Wheeler, David; Wu, Guanming; Yu, Jun; Zhang, Jing; Zhang, Xuanping; Zhang, Yan; Zhao, Zhongming; Zou, Lihua; von Mering, Christian; Structural Variation Working Group, PCAWG; C. Akdemir, Kadir; G. Álvarez, Eva; Baez‐Ortega, Adrian; Beroukhim, Rameen; C. Boutros, Paul; D.L. Bowtell, David; Brors, Benedikt; H. Burns, Kathleen; Busanovich, John; J. Campbell, Peter; Chan, Kin; Chen, Ken; Cortés‐Ciriano, Isidro; Dueso-Barroso, Ana; Dunford, Andrew; A. Edwards, Paul; Estivill, Xavier; Etemadmoghadam, Dariush; Feuerbach, Lars; Lynn Fink, J.; Frenkel‐Morgenstern, Milana; W. Garsed, Dale; Gerstein, Mark; A. Gordenin, Dmitry; Haan, David; E. Haber, James; M. Hess, Julian; Hutter, Barbara; Imieliński, Marcin; Jones, David; Seok Ju, Young; D. Kazanov, Marat; J. 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M. van Deurzen, Carolien; J. van de Vijver, Marc; van’t Veer, Laura; von Mering, Christian

doi:10.1038/s41586-020-1965-x

Public

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Published in Nature • Feb 5, 2020

Authors:

Esther Rheinbay

Morten Muhlig Nielsen

Federico Abascal

Abstract

Abstract The discovery of drivers of cancer has traditionally focused on protein-coding genes 1–4 . Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 5 of the Internat...

Subject

Somatic cell

Genome

Biology

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