A Multi‐action and Multi‐target Ru<sup>II</sup>–Pt<sup>IV</sup> Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

Karges, Johannes; Yempala, Thirumal; Tharaud, Mickaël; Gibson, Dan; Gasser, Gilles

doi:10.1002/anie.201916400

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A Multi‐action and Multi‐target RuII–PtIV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

Shared by NobleBlocks on Mar 11, 2020 • 12:00 AM UTC

Authors:

Johannes Karges

Thirumal Yempala

Mickaël Tharaud

Abstract

Abstract Pt II complexes are commonly used to treat cancer. To reduce their side effects and improve their pharmacological properties, Pt IV complexes are being developed as prodrug candidates that are activated by reduction in cancer cells. Concomitantly, Ru II polypyridine complexes have gained mu...

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