Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension

E. Simpson, Catherine; Y. Chen, Jenny; L. Damico, Rachel; M. Hassoun, Paul; J. Martin, Lisa; Yang, Jun; Nies, Melanie; Griffiths, Megan; Vaidya, Dhananjay; Brandal, Stephanie; W. Pauciulo, Michael; A. Lutz, Katie; W. Coleman, Anna; D. Austin, Eric; Dunbar Ivy, D.; C. Nichols, William; D. Everett, Allen

doi:10.1183/13993003.01761-2019

Public

Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension

Published in European Respiratory Journal • Feb 6, 2020

Authors:

Catherine E. Simpson

Jenny Y. Chen

Rachel L. Damico

Abstract

The pro-inflammatory cytokine interleukin (IL)-6 has been associated with outcomes in small pulmonary arterial hypertension (PAH) cohorts composed largely of patients with severe idiopathic PAH (IPAH). It is unclear whether IL-6 is a marker of critical illness or a mechanistic biomarker of pulmonary...

Subject

Medicine

Phenotype

Pulmonary hypertension

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