New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

Pedron, Julien; Boudot, Clotilde; Brossas, Jean‐Yves; Pinault, Émilie; Bourgeade‐Delmas, Sandra; Sournia‐Saquet, Alix; Boutet-Robinet, Élisa; Destère, Alexandre; Tronnet, Antoine; Bergé, Justine; Bonduelle, Colin; Deraeve, Céline; Pratviel, Geneviève; Stigliani, Jean‐Luc; Paris, Luc; Mazier, Dominique; Corvaisier, Sophie; Since, Marc; Malzert‐Fréon, Aurélie; Wyllie, Susan; Milne, Rachel; H. Fairlamb, Alan; Valentin, Alexis; Courtioux, Bertrand; Verhaeghe, Pierre

doi:10.1021/acsmedchemlett.9b00566

Public

New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

Published in ACS Medicinal Chemistry Letters • Feb 6, 2020

Authors:

Julien Pedron

Clotilde Boudot

Jean‐Yves Brossas

Abstract

High Resolution Image Download MS PowerPoint Slide An antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-nitroquinolin-2(1 H )-one pharmacophore. Fifteen new derivatives were synthesized and evaluated in vitro against L. infantum, T. brucei brucei, and T. cruzi, in paral...

Subject

Trypanosoma brucei

Trypanosoma cruzi

Amastigote

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!