Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

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M. van Deurzen, Carolien; J. van de Vijver, Marc; van’t Veer, L.; von Mering, Christian

doi:10.1038/s41588-019-0576-7

Public

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Published in Nature Genetics • Feb 5, 2020

Authors:

Isidro Cortés-Ciriano

Jake June-Koo Lee

Ruibin Xi

Abstract

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. H...

Subject

Chromothripsis

Biology

Genome

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