Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer

Zhang, Mingjie; Huang, Li-Feng; Ding, Guoping; Huang, Huilian; Cao, Guoliang; Sun, Xu; Lou, Neng; Wei, Qiang; Shen, Tao; Xu, Xiaodong; Cao, Liping; Yan, Qiang

doi:10.1136/jitc-2019-000308

Public

Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer

Published in Journal for ImmunoTherapy of Cancer • Feb 1, 2020

Authors:

Mingjie Zhang

Li-Feng Huang

Guoping Ding

Abstract

Background Pancreatic cancer (PC) is a common malignancy of the digestive system and is characterized by poor prognosis and early metastasis. Tumor immune escape plays an important role in PC progression. Programmed death 1 (PD1) blockade therapy is a promising treatment for patients with PC, but is...

Subject

Pancreatic cancer

Cancer research

Medicine

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