Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001

D. Brown, Paul; Gondi, Vinai; L. Pugh, Stephanie; A. Tomé, Wolfgang; S. Wefel, Jeffrey; S. Armstrong, Terri; Bovi, Joseph; G. Robinson, Clifford; Konski, André; Khuntia, Deepak; R. Grosshans, David; L.S. Benzinger, Tammie; Watkins Bruner, Deborah; R. Gilbert, Mark; Roberge, David; Kundapur, Vijayananda; Devisetty, Kiran; Shah, Sunjay; Y. Usuki, Kenneth; Anderson, Bethany; Stea, Baldassarre; Yoon, Harold; Li, Jing; N. Laack, Nadia; J. Kruser, Tim; J. Chmura, Steven; Shi, Wenyin; Deshmukh, Snehal; P. Mehta, Minesh; A. Kachnic, Lisa; NRG Oncology, for

doi:10.1200/jco.19.02767

Public

Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001

Published in Journal of Clinical Oncology • Feb 14, 2020

Authors:

Paul D. Brown

Vinai Gondi

Stephanie L. Pugh

Abstract

PURPOSE Radiation dose to the neuroregenerative zone of the hippocampus has been found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain radiotherapy (WBRT) is hypothesized to preserve cognition. METHODS This phase III tria...

Subject

Medicine

Memantine

Oncology

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