Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke

Campbell, Bruce; Mitchell, Peter; Churilov, Leonid; Yassi, Nawaf; Kleinig, Timothy; Dowling, Richard; Yan, Bernard; Bush, Steven; Thijs, Vincent; Scroop, Rebecca; Simpson, Marion; Brooks, Mark; Asadi, Hamed; Y. Wu, Teddy; Shah, Darshan; Wijeratne, Tissa; Zhao, Henry; Alemseged, Fana; Ng, Felix; Bailey, Peter; E. Rice, Henry; de Villiers, Laetitia; M. Dewey, Helen; Choi, Philip; Brown, Helen; Redmond, Kendal; Leggett, David; Fink, John; Collecutt, Wayne; Kræmer, Thomas; Krause, Martín; Cordato, Dennis; Field, Deborah; Ma, Henry; O’Brien, Bill; Clissold, Benjamin; Miteff, Ferdinand; Clissold, Anna; Cloud, Geoffrey; Bolitho, Leslie; Bonavia, Luke; Bhattacharya, Arup; A. Wright, A.; Mamun, Abul; O’Rourke, Fintan; Worthington, John; Wong, Andrew; Levi, Christopher; F. Bladin, Christopher; Sharma, Gagan; Desmond, Patricia; Parsons, Mark; A. Donnan, Geoffrey; M. Davis, Stephen; TNK Part 2 investigators, EXTEND-IA; A. Taylor, James; Kurunawai, Craig; Cheong, Edmund; Balabanski, Anna; J. Waters, Michael; Harvey, Jackson; Cagi, Lavenia; Chia, Nicholas; Khoo, Anthony; Drew, Roy; Cranefield, Jennifer; J. Oxley, Thomas; Williams, Cameron; Rodrigues, Edrich; Salvaris, Patrick; Dos Santos, Angela; Ng, Jo-Lyn; Coote, Skye; Beltrame, Carolyn; A. Mackey, Elizabeth; Lagma, Kanaga; McDonald, Amy; M. Jackson, David; Tsoleridis, Jessica; Pesavento, Lauren; Jhamb, Ashu; Brodtmann, Amy; Warwick, Alexandra; Coulton, Bronwyn; Young, Dennis; Whitley, Justin; Bendall, Carol; T.H. Tu, Hans; Celestino, Sherisse; Low, Essie; Sabet, Arman; Mishra, Sachin; Urbi, Berzenn; Frost, Tanya; Chen, Jessie; Kar Chen, Siew; Y Tang, Melissa; Nowak, Kara; Pereira Martins, Rodrigo; Senanayake, Channa; Yam, Charmaine; Barber, Daniel; Bridge, Francesca; Wong, Joseph; Thomas, Grace; Liu, Jennifer; Pachani, Naila; Lee, Rose; Sahathevan, Ramesh; Hair, Casey; Harrington, Timothy; Steinfort, Brendan; Faulder, Kenneth; Day, Susan; J McDougall, Allan; Cappelen‐Smith, Cecilia; Wenderoth, Jason; Cheung, Andrew; Manning, Nathan; Moey, Andrew; Maxwell, Vanessa; G. Phan, Thanh; Singhal, Shaloo; Ly, John; Chong, Winston; V. Chandra, Ronil; Slater, Lee‐Anne; Evans, James; Alchin, Deborah; Talman, Paul; Shaw, Cameron; Malhotra, Abhishek; Makonahalli, Rohitha; J. Spratt, Neil; García-Esperón, Carlos; Kaauwai, Lara; Groot, Patrick; Madan, Anoop; Chung, Carlos; Moore, Andrea; Krones, Robert; Bilkhu, Nancy; Haines, Helen; Eversheim, Franz; Ray, Erin; Coupland, Tessa; Ang, Timothy; L. Winters, Stephen; Brunacci, David; Parker, Geoffrey; Tastula, Kylie; Muller, Claire; Coulthard, Alan; Clouston, John; Mitchell, Ken; Mahady, Kate; Liu, Yvonne; Min Kuang, Ye; Wu, Aileen; Smith, Karen; Stephenson, Michael; Andrew, Emily; Ligtermoet, Matthew; Lee-Archer, Matthew; Fink, John; Beharry, James; Laing, Andrew; Krauß, Martin; Eagle, Jane; Uys, Gerhard; Arthurson, Lauren; Mandaleson, Krishna; Van Berkel, Anne; Grimley, Rohan; Skoien, Wayne; Mahant, Neil; Alan Barber, P.; McGuinness, Ben; Hope, Ayton; Brew, Stefan; Moriarty, Maurice; Zhao, Lily; Sallaberger, Michele; Snow, Barry; Kolbe, John; Stark, R.; T. King, John; Macdonnell, Richard; Attia, John; D’Este, Cate

doi:10.1001/jama.2020.1511

Public

Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke

Published in JAMA • Feb 20, 2020

Authors:

Bruce Campbell

Peter Mitchell

Leonid Churilov

Abstract

Importance: Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase. Objective: To determine whether 0.40 mg/kg of tenecteplase safely improves reperfusion before endovascular thrombectomy vs 0.25 mg/kg of tenecte...

Subject

Medicine

Tenecteplase

Thrombolysis

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