Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial.

C V Campbell, Bruce; J Mitchell, Peter; Churilov, Leonid; Yassi, Nawaf; J Kleinig, Timothy; J Dowling, Richard; Yan, Bernard; J Bush, Steven; Thijs, Vincent; Scroop, Rebecca; Simpson, Marion; Brooks, Mark; Asadi, Hamed; Y Wu, Teddy; G Shah, Darshan; Wijeratne, Tissa; Zhao, Henry; Alemseged, Fana; Ng, Felix; Bailey, Peter; Rice, Henry; de Villiers, Laetitia; M Dewey, Helen; M C Choi, Philip; Brown, Helen; Redmond, Kendal; Leggett, David; N Fink, John; Collecutt, Wayne; Kraemer, Thomas; Krause, Martin; Cordato, Dennis; Field, Deborah; Ma, Henry; O'Brien, Bill; Clissold, Benjamin; Miteff, Ferdinand; Clissold, Anna; C Cloud, Geoffrey; E Bolitho, Leslie; Bonavia, Luke; Bhattacharya, Arup; Wright, Alistair; Mamun, Abul; O'Rourke, Fintan; Worthington, John; A Wong, Andrew; R Levi, Christopher; F Bladin, Christopher; Sharma, Gagan

doi:10.1001/jama.2020.1511

Public

Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial.

Published in JAMA • Apr 7, 2020

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Authors:

Bruce C V Campbell

,

Peter J Mitchell

,

Leonid Churilov

Abstract

Importance: Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase. Objective: To determine whether 0.40 mg/kg of tenecteplase safely improves reperfusion before endovascular thrombectomy vs 0.25 mg/kg of tenecte...

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