Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Wrapp, Daniel; Wang, Nianshuang; S. Corbett, Kizzmekia; A. Goldsmith, Jory; Hsieh, Ching‐Lin; M. Abiona, Olubukola; S. Graham, Barney; S. McLellan, Jason

doi:10.1126/science.abb2507

Public

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Published in Science • Feb 19, 2020

Authors:

Daniel Wrapp

Nianshuang Wang

Kizzmekia S. Corbett

Abstract

The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure developme...

Subject

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

Trimer

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