Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

Ariana, Ardeshir; A. Alturki, Norah; Hajjar, Stephanie; J. Stumpo, Deborah; Tiedje, Christopher; S. Alnemri, Emad; Gaestel, Matthias; J. Blackshear, Perry; Sad, Subash

doi:10.1074/jbc.ra119.011633

Public

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

Published in Journal of Biological Chemistry • Feb 25, 2020

Authors:

Ardeshir Ariana

Norah A. Alturki

Stephanie Hajjar

Abstract

The necrosome is a protein complex required for signaling in cells that results in necroptosis, which is also dependent on tumor necrosis factor receptor (TNF-R) signaling. TNFα promotes necroptosis, and its expression is facilitated by mitogen-activated protein (MAP) kinase–activated protein kinase...

Subject

TLR4

Tristetraprolin

Necroptosis

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