Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

Ariana, Ardeshir; A. Alturki, Norah; Hajjar, Stephanie; J. Stumpo, Deborah; Tiedje, Christopher; S. Alnemri, Emad; Gaestel, Matthias; J. Blackshear, Perry; Sad, Subash

doi:10.1074/jbc.ra119.011633

Public

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

Published in Journal of Biological Chemistry • Feb 25, 2020

Authors:

Ardeshir Ariana

Norah A. Alturki

Stephanie Hajjar

Abstract

mice with graded doses of lipopolysaccharide (LPS) and various inhibitors to evaluate the role of various genes in Toll-like receptor 4 (TLR4)-induced necroptosis. Necrosome signaling, cytokine production, and cell death were evaluated by immunoblotting, ELISA, and cell death assays, respectively. W...

Subject

TLR4

Tristetraprolin

Necroptosis

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