Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.

Naoya, Yamada,; Tadayoshi, Karasawa,; Hiroaki, Kimura,; Sachiko, Watanabe,; Takanori, Komada,; Ryo, Kamata,; Ariunaa, Sampilvanjil,; Junya, Ito,; Kiyotaka, Nakagawa,; Hiroshi, Kuwata,; Shuntaro, Hara,; Koichi, Mizuta,; Yasunaru, Sakuma,; Naohiro, Sata,; Masafumi, Takahashi,

doi:10.1038/s41419-020-2334-2

Public

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.

Published in Cell death & disease • Feb 24, 2020

Authors:

Yamada, Naoya

Karasawa, Tadayoshi

Kimura, Hiroaki

Abstract

Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure. Although hepatocyte cell death is considered to be the critical event in APAP-induced hepatotoxicity, the underlying mechanism remains unclear. Ferroptosis is a newly discovered type of cell death that is caused by ...

Subject

Acetaminophen

Animals

Antioxidants

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!