A cell atlas of human thymic development defines T cell repertoire formation

Park, Jong-Eun; A. Botting, Rachel; Domínguez Conde, Cecilia; Popescu, Dorin-Mirel; Lavaert, Marieke; J. Kunz, Daniel; Goh, Issac; Stephenson, Emily; Ragazzini, Roberta; Tuck, Elizabeth; Wilbrey-Clark, Anna; Roberts, Kenny; R. Kedlian, Veronika; R. Ferdinand, John; He, Xiaoling; Webb, Simone; Maunder, Daniel; Vandamme, Niels; T. Mahbubani, Krishnaa; Polański, Krzysztof; Mamanova, Lira; Bolt, Liam; Crossland, David; De Rita, Fabrizio; Fuller, Andrew; Filby, Andrew; Reynolds, Gary; Dixon, David; Saeb‐Parsy, Kourosh; Lisgo, Steven; J. Henderson, Deborah; Vento‐Tormo, Roser; Ali Bayraktar, Omer; A. Barker, Roger; B. Meyer, Kerstin; Saeys, Yvan; Bonfanti, Paola; Behjati, Sam; R. Clatworthy, Menna; Taghon, Tom; Haniffa, Muzlifah; A. Teichmann, Sarah

doi:10.1126/science.aay3224

Public

A cell atlas of human thymic development defines T cell repertoire formation

Published in Science • Feb 20, 2020

Authors:

Jong-Eun Park

Rachel A. Botting

Cecilia Domínguez Conde

Abstract

Thymus development, cell by cell The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a full immune complement that contains the necessary variation to ...

Subject

Immune system

Biology

Cell biology

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