Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Simón, Jorge; Núñez-García, Maitane; Fernández‐Tussy, Pablo; Barbier‐Torres, Lucía; Fernández‐Ramos, David; Gómez‐Santos, Beatriz; Buqué, Xabier; Lopitz‐Otsoa, Fernando; Goikoetxea‐Usandizaga, Naroa; Serrano‐Maciá, Marina; Rodríguez‐Agudo, Rubén; Bizkarguenaga, Maider; Zubiete‐Franco, Imanol; Gutiérrez‐de Juan, Virginia; Cabrera, Diana; Alonso, Cristina; Iruzubieta, Paula; Romero‐Gómez, Manuel; van Liempd, Sebastiaan; Castro, Azucena; Nogueiras, Rubén; Varela‐Rey, Marta; Manuel Falcón‐Pérez, Juan; Villa, Erica; Crespo, Javier; C. Lu, Shelly; M. Mato, José; Aspichueta, Patricia; C. Delgado, Teresa; Luz Martínez‐Chantar, Maria

doi:10.1016/j.cmet.2020.01.013

Public

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Published in Cell Metabolism • Feb 21, 2020

Authors:

Jorge Simón

Maitane Núñez-García

Pablo Fernández‐Tussy

Abstract

Non-alcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatic fat in an inflammatory/fibrotic background. Herein, we show that the hepatic high-activity glutaminase 1 isoform (GLS1) is overexpressed in NASH. Importantly, GLS1 inhibition reduces lipid content in choline and/or ...

Subject

Steatohepatitis

Glutaminase

Biochemistry

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