Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease

D. Mosley, Jonathan; K. Gupta, Deepak; Tan, Jingyi; Yao, Jie; S. Wells, Quinn; M. Shaffer, Christian; Kundu, Suman; Robinson‐Cohen, Cassianne; M. Psaty, Bruce; S. Rich, Stephen; S. Post, Wendy; Guo, Xiuqing; I. Rotter, Jerome; M. Roden, Dan; E. Gerszten, Robert; J. Wang, Thomas

doi:10.1001/jama.2019.21782

Public

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease

Published in JAMA • Feb 18, 2020

Authors:

Jonathan D. Mosley

Deepak K. Gupta

Jingyi Tan

Abstract

Importance: Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening. Objective: To determine whether a polygenic risk score improves prediction of CHD compared with a guideline-recommended clinical...

Subject

Medicine

Framingham Risk Score

Interquartile range

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