Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Kebede Merid, Simon; Novoloaca, Alexei; C. Sharp, Gemma; K. Küpers, Leanne; T. Kho, Alvin; Roy, Ritu; Gao, Lu; Annesi‐Maesano, Isabella; Jain, Pooja; Plusquin, Michelle; Kogevinas, Manolis; Allard, Catherine; O. L. Vehmeijer, Florianne; Kazmi, Nabila; A. Salas, Lucas; I. Rezwan, Faisal; Zhang, Hongmei; Sebért, Sylvain; Czamara, Darina; L. Rifas‐Shiman, Sheryl; E. Melton, Phillip; A. Lawlor, Debbie; Pershagen, Göran; V. Breton, Carrie; Huen, Karen; Baïz, Nour; Gagliardi, Luigi; S. Nawrot, Tim; Corpeleijn, Eva; Perron, Patrice; Duijts, Liesbeth; A. Nøhr, Ellen; Bustamante, Mariona; Ewart, Susan; Karmaus, Wilfried; Zhao, Shanshan; M. Page, Christian; Herceg, Zdenko; Järvelin, Marjo‐Riitta; Lahti, Jari; Baccarelli, Andrea; Anderson, Denise; Kachroo, Priyadarshini; L. Relton, Caroline; Bergström, Anna; Eskenazi, Brenda; Hussain Soomro, Munawar; Vineis, Paolo; Snieder, Harold; Bouchard, Luigi; W. V. Jaddoe, Vincent; I. A. Sørensen, Thorkild; Vrijheid, Martine; Hasan Arshad, Syed; W. Holloway, John; E. Håberg, Siri; Magnus, Per; Dwyer, Terence; B. Binder, Elisabeth; L. DeMeo, Dawn; M. Vonk, Judith; P. Newnham, John; G. Tantisira, Kelan; Kull, Inger; L. Wiemels, Joseph; Heude, Barbara; Sunyer, Jordi; Nystad, Wenche; Cheng Munthe‐Kaas, Monica; Räikkönen, Katri; Oken, Emily; Huang, Rae‐Chi; T. Weiss, Scott; M. Antó, Josep; Bousquet, Jean; Kumar, Ashish; Söderhäll, Cilla; Almqvist, Catarina; Cárdenas, Andrés; Gruzieva, Olena; Xu, Cheng‐Jian; E. Reese, Sarah; Kere, Juha; Brodin, Petter; Solomon, Olivia; Wielscher, Matthias; Holland, Nina; Ghantous, Akram; Hivert, Marie‐France; F. Felix, Janine; H. Koppelman, Gerard; J. London, Stephanie; Melén, Erik

doi:10.1186/s13073-020-0716-9

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Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Published in Genome Medicine • Mar 2, 2020

Authors:

Simon Kebede Merid

Alexei Novoloaca

Gemma C. Sharp

Abstract

BACKGROUND: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. ME...

Subject

Epigenome

DNA methylation

Meta-analysis

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