YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

J. Thompson, Barry

doi:10.1002/bies.201900162

Public

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

Published in BioEssays • Mar 4, 2020

Authors:

Barry J. Thompson

Abstract

The transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1) are frequently activated during the growth and progression of many solid tumors, including lung, colorectal, breast, pancreatic, and liver carcinomas as well as melanoma and glioma. YAP/TAZ bind to TEAD-family co-activators to drive ...

Subject

Hippo signaling pathway

Cancer research

Metastasis

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