Interleukin‐1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST‐Segment–Elevation Myocardial Infarction

Abbate, Antonio; R. Trankle, Cory; F. Buckley, Leo; J. Lipinski, Michael; Appleton, Darryn; Kadariya, Dinesh; M. Canada, Justin; Carbone, Salvatore; S. Roberts, Charlotte; Abouzaki, Nayef; Melchior, Ryan; Christopher, Sanah; Turlington, Jeremy; Mueller, George; P. Garnett, James; S. Thomas, Christopher; Markley, Roshanak; F. Wohlford, George; Puckett, Laura; Medina de Chazal, Horacio; Guido Chiabrando, Juan; Bressi, Edoardo; Giuseppe Del Buono, Marco; Schatz, Aaron; Vo, Chau; L. Dixon, Dave; Biondi‐Zoccai, Giuseppe; C. Kontos, Michael; W. Van Tassell, Benjamín

doi:10.1161/jaha.119.014941

Public

Interleukin‐1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST‐Segment–Elevation Myocardial Infarction

Published in Journal of the American Heart Association • Mar 3, 2020

Authors:

Antonio Abbate

Cory R. Trankle

Leo F. Buckley

Abstract

Background ST ‐segment–elevation myocardial infarction is associated with an intense acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 blockade with anakinra significantly reduced the area under the curve for hsCRP (high sensitivity C‐reactive protein) levels dur...

Subject

Medicine

Myocardial infarction

ST segment

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