p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

Che, Hui; Li, Jie; Li, You; Ma, Cheng; Liu, Huan; Qin, Jingyi; Dong, Jianghui; Zhang, Zhen; J. Xian, Cory; Miao, Dengshun; Wang, Liping; Ren, Yongxin

doi:10.7554/elife.52570

Public

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

Published in eLife • Mar 3, 2020

Authors:

Hui Che

Jie Li

You Li

Abstract

The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-ind...

Subject

Oxidative stress

Senescence

Biology

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