m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

Jin, Dan; Guo, Jiwei; Wu, Yan; Yang, Lijuan; Wang, Xiaohong; Du, Jing; Dai, Juanjuan; Chen, Weiwei; Gong, Kaikai; Miao, Shuang; Li, Xuelin; Sun, Hongliang

doi:10.1186/s12943-020-01161-1

Public

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

Published in Molecular Cancer • Feb 27, 2020

Authors:

Dan Jin

Jiwei Guo

Yan Wu

Abstract

Abstract Background The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP is associated with the development of many human cancers. However, the mechanism whereby ALKBH5 regulates YAP expression...

Subject

Biology

Demethylase

Cancer research

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