Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

Murugesh Karunakaran, Mohindar; R. Willcox, Carrie; Salim, Mahboob; Paletta, Daniel; Suzann Fichtner, Alina; Noll, Angela; Starick, Lisa; Nöhren, Anna; R. Begley, Charlotte; A. Berwick, Katie; A. G. Chaleil, Raphaël; Pitard, Vincent; Déchanet‐Merville, Julie; A. Bates, Paul; Kimmel, Brigitte; J. Knowles, Timothy; Kunzmann, Volker; Walter, Lutz; Jeeves, Mark; Mohammed, Fiyaz; E. Willcox, Benjamin; Herrmann, Thomas

doi:10.1016/j.immuni.2020.02.014

Public

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

Published in Immunity • Mar 1, 2020

Authors:

Mohindar Murugesh Karunakaran

Carrie R. Willcox

Mahboob Salim

Abstract

Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 (BTN3A1), a protein structurally related to the B7 family of costimulatory molecules, is necessary but insufficient for this process. We performed...

Subject

Biology

Germline

T-cell receptor

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