Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Sencio, Valentin; Barthélémy, Adeline; P. Tavares, Luciana; Machado, Marina; Soulard, Daphnée; Cuinat, Céline; Martins Queiroz‐Junior, Celso; Noordine, Marie-Louise; Salomé‐Desnoulez, Sophie; Deryuter, Lucie; Foligné, Benoît; Wahl, Céline; Frisch, Benoı̂t; T. Vieira, Angélica; Paget, Christophe; Milligan, Graeme; Ulven, Trond; Wolowczuk, Isabelle; Faveeuw, Christelle; Le Goffic, Ronan; Thomas, Muriel; Ferreira, Stéphanie; Martins Teixeira, Mauro; Trottein, François

doi:10.1016/j.celrep.2020.02.013

Public

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Published in Cell Reports • Mar 1, 2020

Authors:

Valentin Sencio

Adeline Barthélémy

Luciana P. Tavares

Abstract

Secondary bacterial infections often complicate viral respiratory infections. We hypothesize that perturbation of the gut microbiota during influenza A virus (IAV) infection might favor respiratory bacterial superinfection. Sublethal infection with influenza transiently alters the composition and fe...

Subject

Superinfection

Dysbiosis

Short-chain fatty acid

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