Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Liu, Wei; Rong, Yuluo; Wang, Jiaxing; Zhou, Zheng; Ge, Xuhui; Ji, Chengyue; Jiang, Dongdong; Gong, Fangyi; Li, Linwei; Chen, Jian; Zhao, Shujie; Kong, Fanqi; Gu, Changjiang; Fan, Jin; Cai, Weihua

doi:10.1186/s12974-020-1726-7

Public

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Published in Journal of Neuroinflammation • Feb 4, 2020

Authors:

Wei Liu

Yuluo Rong

Jiaxing Wang

Abstract

BACKGROUND: Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potential for promoting functional behavioral recovery following SCI. However, MSCs are...

Subject

Mesenchymal stem cell

Exosome

Spinal cord injury

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