Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation

Ji, Qing; Zhou, Lihong; Sui, Hua; Yang, Liu; Wu, Xinnan; Song, Qing; Jia, Ru; Li, Ruixiao; Sun, Jian; Wang, Ziyuan; Liu, Ningning; Feng, Yuanyuan; Sun, Xiaoting; Cai, Gang; Cai, Gang; Feng, Yu; Cao, Yihai; Cao, Yihai; Cai, Guoxiang; Cai, Guoxiang; Wang, Yan; Li, Qi

doi:10.1038/s41467-020-14869-x

Public

Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation

Published in Nature Communications • Mar 5, 2020

Authors:

Qing Ji

Lihong Zhou

Hua Sui

Abstract

Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understood. Here we show that in a colorectal cancer (CRC) model, primary tumors release integrin be...

Subject

Stromal cell

Cancer research

Metastasis

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