The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

Ding, Lei; Cao, Jiaqi; Lin, Wen-Shan; Chen, Hongjian; Xiong, Xianhui; Ao, Hongshun; Yu, Min; Lin, Jie; Cui, Qinghua

doi:10.3390/ijms21061960

Public

The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

Published in International Journal of Molecular Sciences • Mar 13, 2020

Authors:

Lei Ding

Jiaqi Cao

Wen-Shan Lin

Abstract

Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory enzymes involved in cell proliferation through regulating cell-cycle checkpoints and transcriptional events in respons...

Subject

Cyclin-dependent kinase

Kinase

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