Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers

D. Bradley, Sherille; H. Talukder, Amjad; Lai, Ivy; K. Davis, Rebecca; M. Álvarez, Héctor; Tiriac, Hervé; Zhang, Minying; Chiu, Yulun; Melendez, Brenda; R. Jackson, Kyle; Katailiha, Arjun; M. Sonnemann, Heather; Li, Fenge; Kang, Ya’an; Qiao, Na; Pan, Bih-Fang; L. Lorenzi, Philip; W. Hurd, Mark; A. Mittendorf, Elizabeth; B. Peterson, Christine; Javle, Milind; A. Bristow, Christopher; P. Kim, Michael; A. Tuveson, David; H. Hawke, David; Kopetz, Scott; A. Wolff, Robert; Hwu, Patrick; Maitra, Anirban; Roszik, Jason; Yee, Cassian; Lizée, Gregory

doi:10.1038/s41467-020-19141-w

Public

Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers

Published in Nature Communications • Oct 21, 2020

Authors:

Sherille D. Bradley

Amjad H. Talukder

Ivy Lai

Abstract

Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class I-bou...

Subject

Cancer research

Antigen

CTL*

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