Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

Yu, Zhuo; Guo, Jianfeng; Hu, Mengying; Gao, Yueqiu; Huang, Leaf

doi:10.1021/acsnano.0c00708

Public

Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

Published in ACS Nano • Mar 18, 2020

Authors:

Zhuo Yu

Jianfeng Guo

Mengying Hu

Abstract

Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is among the deadliest malignancies. Doxorubicin widely used in transarterial chemotherapy in HCC can induce immunogenic cell death (ICD), but the resulting immunogenicity is still weak. We aim to seek a strategy for imp...

Subject

Hepatocellular carcinoma

Doxorubicin

Mitophagy

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