SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation

Liu, Xiaoming; Liu, Jianye; Xiao, Wen; Zeng, Qinghai; Bo, Hao; Zhu, Yuxing; Gong, Lian; He, Dong; Xing, Xiaowei; Li, Ruhong; Zhou, Ming; Xiong, Wei; Zhou, Yanhong; Zhou, Jianda; Li, Xiaohui; Guo, Fei; Xu, Canxia; Chen, Xiong; Wang, Xiaoyan; Wang, Fen; Wang, Qiang; Cao, Ke

doi:10.1002/hep.31222

Public

SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation

Published in Hepatology • Mar 10, 2020

Authors:

Xiaoming Liu

Jianye Liu

Wen Xiao

Abstract

Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered in HCC, and its presence is positively correlated with malignancy and metastasis. N 6 ‐methyladenosine (m 6 A) is the most ...

Subject

Ubiquitin ligase

N6-Methyladenosine

Chemistry

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