Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

G.S. Chirivi, Renato; W.G. van Rosmalen, Jos; van der Linden, Maarten; Euler, Maximilien; Schmets, G.; S. Bogatkevich, Galina; Kambas, Konstantinos; Hahn, Jonas; Braster, Quinte; Soehnlein, Oliver; Hoffmann, Markus; H. G. van Es, Helmuth; Raats, Jos

doi:10.1038/s41423-020-0381-3

Public

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

Published in Cellular and Molecular Immunology • Mar 20, 2020

Authors:

Renato G.S. Chirivi

Jos W.G. van Rosmalen

Maarten van der Linden

Abstract

Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models, indicating that NETs are p...

Subject

Neutrophil extracellular traps

In vivo

Inflammation

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