Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury

Huang, Fengming; Zhang, Cong; Liu, Qiang; Zhao, Yan; Zhang, Yuqing; Qin, Yuhao; Li, Xiao; Li, Chang; Zhou, Cong‐Zhao; Jin, Ningyi; Jiang, Chengyu

doi:10.1371/journal.ppat.1008341

Public

Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury

Published in PLoS Pathogens • Mar 16, 2020

Authors:

Fengming Huang

Cong Zhang

Qiang Liu

Abstract

Infection with avian influenza A H5N1 virus results in acute lung injury (ALI) and has a high mortality rate (52.79%) because there are limited therapies available for treatment. Drug repositioning is an economical approach to drug discovery. We developed a method for drug repositioning based on hig...

Subject

Pharmacology

Medicine

Drug repositioning

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