Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models

Kim, Kyeong-A; Kim, Donghyun; Kim, Jeong‐Hyeon; Shin, Young‐Jun; Sun Kim, Eun; Akram, Muhammad; Kim, Eun-Hye; Majid, Arshad; Baek, Seung‐Hoon; Bae, Ok‐Nam

doi:10.1186/s12987-020-00182-8

Public

Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models

Published in Fluids and Barriers of the CNS • Mar 14, 2020

Authors:

Kyeong-A Kim

Donghyun Kim

Jeong‐Hyeon Kim

Abstract

BACKGROUND: The blood-brain barrier (BBB) maintains homeostasis of the brain environment by tightly regulating the entry of substances from systemic circulation. A breach in the BBB results in increased permeability to potentially toxic substances and is an important contributor to amplification of ...

Subject

Occludin

Autophagy

Blood–brain barrier

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