Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

W. van der Pluijm, Rob; Tripura, Rupam; M. Hoglund, Richard; Pyae Phyo, Aung; Lek, Dysoley; ul Islam, Akhter; R. Anvikar, Anupkumar; Satpathi, Parthasarathi; Satpathi, Sanghamitra; Kumari Behera, Prativa; Tripura, Amar; Baidya, Subrata; A. Onyamboko, Marie; Hoàng Châu, Nguyễn; Sovann, Yok; Suon, Seila; Sreng, Sokunthea; Mao, Sivanna; Oun, Savuth; Yen, Sovannary; Amaratunga, Chanaki; Chutasmit, Kitipumi; Saelow, Chalermpon; Runcharern, Ratchadaporn; Kaewmok, Weerayuth; Thi Hoa, Nhu; Viet Thanh, Ngo; Hanboonkunupakarn, Borimas; J. Callery, James; Mohanty, D.; Heaton, James; Thant, Myo; Gantait, Kripasindhu; Ghosh, Tarapada; Amato, Roberto; D. Pearson, Richard; G. Jacob, Christopher; Gonçalves, Sónia; Mukaka, Mavuto; Waithira, Naomi; J. Woodrow, Charles; P. Grobusch, Martin; van Vugt, Michèle; M. Fairhurst, Rick; Yeong Cheah, Phaik; J. Peto, Thomas; von Seidlein, Lorenz; Dhorda, Mehul; J. Maude, Richard; Winterberg, Markus; Nguyen, Thuy-Nhien; Kwiatkowski, Dominic; Imwong, Mallika; Jittamala, Podjanee; Lin, Khin; Maung Hlaing, Tin; Chotivanich, Kesinee; Huy, Rekol; Fanello, Caterina; A. Ashley, Elizabeth; Mayxay, Mayfong; N. Newton, Paul; Tinh Hien, Tran; Valecha, Neena; Smithuis, Frank; Pukrittayakamee, Sasithon; Faiz, Abul; Miotto, Olivo; Tärning, Joel; Day, Nicholas; J. White, Nicholas; M. Dondorp, Arjen; W. van der Pluijm, Rob; Tripura, Rupam; M. Hoglund, Richard; Pyae Phyo, Aung; Lek, Dysoley; ul Islam, Akhter; R. Anvikar, Anupkumar; Satpathi, Parthasarathi; Satpathi, Sanghamitra; Kumari Behera, Prativa; Tripura, Amar; Baidya, Subrata; A. Onyamboko, Marie; Hoàng Châu, Nguyễn; Sovann, Yok; Suon, Seila; Sreng, Sokunthea; Mao, Sivanna; Oun, Savuth; Yen, Sovannary; Amaratunga, Chanaki; Chutasmit, Kitipumi; Saelow, Chalermpon; Runcharern, Ratchadaporn; Kaewmok, Weerayuth; Thi Hoa, Nhu; Viet Thanh, Ngo; Hanboonkunupakarn, Borimas; J. Callery, James; Mohanty, D.; Heaton, James; Thant, Myo; Gantait, Kripasindhu; Ghosh, Tarapada; Amato, Roberto; D. Pearson, Richard; G. Jacob, Christopher; Gonçalves, Sónia; Mukaka, Mavuto; Waithira, Naomi; J. Woodrow, Charles; P. Grobusch, Martin; van Vugt, Michèle; M. Fairhurst, Rick; Yeong Cheah, Phaik; J. Peto, Thomas; von Seidlein, Lorenz; Dhorda, Mehul; J. Maude, Richard; Winterberg, Markus; Nguyen, Thuy-Nhien; Kwiatkowski, Dominic; Imwong, Mallika; Jittamala, Podjanee; Lin, Khin; Maung Hlaing, Tin; Chotivanich, Kesinee; Huy, Rekol; Fanello, Caterina; A. Ashley, Elizabeth; Mayxay, Mayfong; N. Newton, Paul; Tinh Hien, Tran; Valeche, Neena; Smithuis, Frank; Pukrittayakamee, Sasithon; Faiz, Abul; Miotto, Olivo; Tärning, Joel; Day, Nicholas; J. White, Nicholas; M. Dondorp, Arjen

doi:10.1016/s0140-6736(20)30552-3

Public

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

Published in The Lancet • Mar 11, 2020

Authors:

Rob W. van der Pluijm

Rupam Tripura

Richard M. Hoglund

Abstract

BACKGROUND: Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide eff...

Subject

Artemisinin

Malaria

Medicine

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