Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Fuk‐Woo Chan, Jasper; Zhang, Jinxia; Yuan, Shuofeng; Kwok‐Man Poon, Vincent; Chung‐Sing Chan, Chris; Chak-Yiu Lee, Andrew; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah; Wen, Lei; Liang, Ronghui; Cao, Jianli; Chen, Yanxia; Tang, Kaiming; Luo, Cuiting; Cai, Jian‐Piao; Kok, Kin‐Hang; Chu, Hin; Chan, Kwok‐Hung; Sridhar, Siddharth; Chen, Zhiwei; Chen, Honglin; Kai‐Wang To, Kelvin; Yuen, Kwok‐Yung

doi:10.1093/cid/ciaa325

Public

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Published in Clinical Infectious Diseases • Mar 26, 2020

Authors:

Jasper Fuk‐Woo Chan

Jinxia Zhang

Shuofeng Yuan

Abstract

BACKGROUND: A physiological small-animal model that resembles COVID-19 with low mortality is lacking. METHODS: Molecular docking on the binding between angiotensin-converting enzyme 2 (ACE2) of common laboratory mammals and the receptor-binding domain of the surface spike protein of SARS-CoV-2 sugge...

Subject

Hamster

Mesocricetus

Virology

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