Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Fuk-Woo Chan, Jasper; Jinxia Zhang, Anna; Yuan, Shuofeng; Kwok-Man Poon, Vincent; Chung-Sing Chan, Chris; Chak-Yiu Lee, Andrew; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah; Wen, Lei; Liang, Ronghui; Cao, Jianli; Chen, Yanxia; Tang, Kaiming; Luo, Cuiting; Cai, Jian-Piao; Kok, Kin-Hang; Chu, Hin; Chan, Kwok-Hung; Sridhar, Siddharth; Chen, Zhiwei; Chen, Honglin; Kai-Wang To, Kelvin; Yuen, Kwok-Yung

doi:10.1093/cid/ciaa325

Public

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Shared by NobleBlocks on Mar 26, 2020 • 12:00 AM UTC

Authors:

Jasper Fuk-Woo Chan

Anna Jinxia Zhang

Shuofeng Yuan

Abstract

Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between angiotensin-converting enzyme 2 (ACE2) of common laboratory mammals and the receptor-binding domain of the surface spike protein of SARS-CoV-...

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