The rRNA m<sup>6</sup>A methyltransferase METTL5 is involved in pluripotency and developmental programs.

VV, Ignatova; P, Stolz; S, Kaiser; TH, Gustafsson; PR, Lastres; A, Sanz-Moreno; YL, Cho; OV, Amarie; A, Aguilar-Pimentel; T, Klein-Rodewald; J, Calzada-Wack; L, Becker; S, Marschall; M, Kraiger; L, Garrett; C, Seisenberger; SM, Hölter; K, Borland; De Logt E, Van; PWTC, Jansen; MP, Baltissen; M, Valenta; M, Vermeulen; W, Wurst; V, Gailus-Durner; H, Fuchs; de Angelis M, Hrabe; OJ, Rando; SM, Kellner; S, Bultmann; R, Schneider

doi:10.1101/gad.333369.119

Public

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.

Shared by NobleBlocks on Mar 26, 2020 • 12:00 AM UTC

Authors:

Ignatova VV

Stolz P

Kaiser S

Abstract

Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, our mechanistic understanding of the enzymes catalyzing these modifications, their substrates and biological functions, remains vague. Amongst RNA modifications N6-methyladenosine (m6A) is widespread ...

Subject

Pluripotency

Methyltransferase

M6a

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