Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation

Gao, Ting; Hu, Mingdong; Zhang, Xiaopeng; Li, Hongzhen; Zhu, Lin; Liu, Hainan; Dong, Qincai; Zhang, Zhang; Wang, Zhongyi; Hu, Yong; Fu, Yangbo; Jin, Yanwen; Li, Kaitong; Zhao, Songtao; Xiao, Yongjiu; Luo, Shuping; Li, Lufeng; Zhao, Lingfang; Liu, Junli; Zhao, Huailong; Liu, Yue; Yang, Weihong; Peng, Jing; Chen, Xiaoyu; Li, Ping; Liu, Yaoning; Xie, Yonghong; Song, Jibo; Zhang, Lu; Ma, Qingjun; Bian, Xiuwu; Chen, Wei; Liu, Xuan; Mao, Qing; Cao, Cheng

doi:10.1101/2020.03.29.20041962

Public

Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation

Published in medRxiv • Mar 30, 2020

Authors:

Ting Gao

Mingdong Hu

Xiaopeng Zhang

Abstract

Abstract An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2 pathogenesis and lethality, but the mechanism remains unclear. In this study, the N proteins of SARS-CoV, MERS-CoV and SARS-CoV-2 were found to bind to MASP-2, the key serine protease in the lectin pathway of comp...

Subject

Complement system

Lectin pathway

Coronavirus

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