The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Xie, Jingyuan; Liu, Lili; Mladkova, Nikol; Li, Yifu; Ren, Hong; Wang, Weiming; Cui, Zhao; Lin, Li; Hu, X.; Yu, Xialian; Xu, Jing; Liu, Gang; Çalışkan, Yaşar; Sidore, Carlo; Balderes, Olivia; J. Rosen, Raphael; Bodria, Monica; Zanoni, Francesca; Y. Zhang, Jun; Krithivasan, Priya; Mehl, Karla; Marasà, Maddalena; Khan, Atlas; Ozay, Fatih; A. Canetta, Pietro; S. Bomback, Andrew; B. Appel, Gerald; Sanna‐Cherchi, Simone; G. Sampson, Matthew; Mariani, Laura; Perkowska‐Ptasińska, Agnieszka; Durlik, Magdalena; Mucha, Krzysztof; Moszczuk, Barbara; Foroncewicz, Bartosz; Pączek, Leszek; Habura, Ireneusz; Ars, Elisabet; Ballarín, José; Mani, Laila-Yasmin; Vogt, Bruno; Öztürk, Savaş; Yıldız, Abdülmecit; Seyahi, Nurhan; Arikan, Hakkı; Koç, Mehmet; Baştürk, Taner; E. Karahan, Gonca; Usta Akgül, Sebahat; Şükrü Sever, Mehmet; Zhang, Dan; Santoro, Domenico; Bonomini, Mario; Londrino, Francesco; Gesualdo, Loreto; Reiterová, Jana; Tesař, Vladimı́r; Izzi, Claudia; Savoldi, Silvana; Spotti, Donatella; Marcantoni, Carmelita; Messa, Piergiorgio; Galliani, Marco; Roccatello, Dario; Granata, Simona; Zaza, Gianluigi; Lugani, Francesca; Marco Ghiggeri, Gian; Pisani, Isabella; Allegri, Landino; Sprangers, Ben; Park, Jin‐Ho; Cho, Belong; Su Kim, Yon; Ki Kim, Dong; Suzuki, Hitoshi; Amoroso, Antonio; Cattran, Daniel; C. Fervenza, Fernando; Pani, Antonello; Hamilton, Patrick; Harris, Shelly; Gupta, Sanjana; Cheshire, Chris; Dufek, Stephanie; Issler, Naomi; J. Pepper, Ruth; Connolly, John; H. Powis, Stephen; Böckenhauer, Detlef; Stanescu, Horia; Ashman, Neil; J. F. Loos, Ruth; E. Kenny, Eimear; Wuttke, Matthias; Eckardt, Kai‐Uwe; Köttgen, Anna; M. Hofstra, Julia; J. H. Coenen, Marieke; A. Kiemeney, Lambertus; Akilesh, Shreeram; Kretzler, Matthias; H. Beck, Laurence; Stengel, Bénédicte; Dêbiec, Hanna; Ronco, Pierre; F.M. Wetzels, Jack; Żołędziewska, Magdalena; Cucca, Francesco; Ionita‐Laza, Iuliana; Lee, Hajeong; Hoxha, Elion; A.K. Stahl, Rolf; Brenchley, Paul; Scolari, Francesco; Zhao, Ming‐Hui; G. Gharavi, Ali; Kleta, Robert; Chen, Nan; Kiryluk, Krzysztof

doi:10.1038/s41467-020-15383-w

Public

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Published in Nature Communications • Mar 30, 2020

Authors:

Jingyuan Xie

Lili Liu

Nikol Mladkova

Abstract

Abstract Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 ( rs230540, OR = 1.25, P ...

Subject

Genome-wide association study

Locus (genetics)

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