Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Liu, M.C.; R. Oxnard, Geoffrey; A. Klein, Eric; Swanton, Charles; V. Seiden, Michael; Seiden, M.V.; C. Liu, Minetta; R. Oxnard, Geoffrey; A. Klein, Eric; A. Smith, David; Richards, Donald; J. Yeatman, Timothy; Lee Cohn, Allen; L. Lapham, Rosanna; Clément, Jessica; S. Parker, Alexander; K. Tummala, Mohan; McIntyre, Kristi; A. Sekeres, Mikkael; H. Bryce, Alan; D. Siegel, Robert; Wang, Xuezhong; Cosgrove, David; R. Abu‐Rustum, Nadeem; C. Trent, Jonathan; D. Thiel, David; Becerra, Carlos; Agrawal, Manish; Garbo, Lawrence; K. Giguere, Jeffrey; M. Michels, Ross; P. Harris, Ronald; Richey, Stephen; A. McCarthy, Timothy; Waterhouse, David; J. Couch, Fergus; Wilks, Sharon; Krie, Amy; Balaraman, Rama; Restrepo, Álvaro; W. Meshad, Michael; Rieger‐Christ, Kimberly; Sullivan, Travis; Lee, Christine; Greenwald, Daniel; Oh, William; Tsao, Che‐Kai; Fleshner, Neil; F. Kennecke, Hagen; Khalil, Maged; R. Spigel, David; Manhas, Atisha; Ulrich, Brian; Kovoor, P.; Stokoe, Christopher; Courtright, Jay; Yimer, Habte; Larson, Timothy; Swanton, Charles; V. Seiden, Michael; V. Seiden, Michael; R. Cummings, Steven; Absalan, Farnaz; E. Alexander, Gregory; C. Allen, Brian; Amini, Hamed; M. Aravanis, Alexander; Bagaria, Siddhartha; Bazargan, Leila; F. Beausang, John; R. Berman, Jennifer; Betts, Craig; W. Blocker, Alexander; Bredno, Joerg; Calef, Robert; Cann, Gordon; G. Carter, Jeremy; Chang, Christopher; Chawla, Hemanshi; Chen, Xiaoji; C. Chien, Tom; Civello, Daniel; Davydov, Konstantin; Demas, Vasiliki; Desai, Mohini; Dong, Zhao; Fayzullina, Saniya; P. Fields, Alexander; Filippova, Darya; Freese, Peter; T. Fung, Eric; Gnerre, Sante; Gross, Samuel; Halks‐Miller, Meredith; P. Hall, Megan; Hartman, Anne‐Renee; Hou, Chenlu; Hubbell, Earl; Hunkapiller, Nathan; A. Jagadeesh, Karthik; Jamshidi, Arash; Jiang, Roger; Jung, Byoungsok; Kim, Tae‐Hyung; D. Klausner, Richard; N. Kurtzman, Kathryn; Lee, Mark; Liu, Hai; A. Lipson, Jafi; Liu, Hai; Liu, Qin‐Wen; Lopatin, Margarita; Maddala, Tara; Cyrus Maher, M.; Melton, Collin; Mich, Andrea; Nautiyal, Shivani; Newman, Jonathan; Newman, Joshua; Nicula, Virgil; Nicolaou, Cosmos; Nikolic, Ongjen; Pan, Wenying; Patel, Shilpen; A. Prins, Sarah; P. Rava, Richard; Ronaghi, Neda; Sakarya, Onur; Vijaya Satya, Ravi; Schellenberger, Jan; Scott, Eric; J. Sehnert, Amy; Shaknovich, Rita; Shanmugam, Avinash; C. Shashidhar, K.; Shen, Ling; Shenoy, Archana; Shojaee, Seyedmehdi; Singh, Pranav; K. Steffen, Kristan; Tang, Susan; Toung, Jonathan; Valouev, Anton; Venn, Oliver; T. Williams, Richard; Wu, Tony; Xu, Hui; Yakym, Christopher; Yang, Xiao; L. Yecies, Jessica; S. Yip, Alexander; Youngren, Jack; Yue, Jeanne; Zhang, Lori; Zhang, Lily; Zhang, Lori; Zhang, Nan; Curtis, Christina; A. Berry, Donald

doi:10.1016/j.annonc.2020.02.011

Public

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Published in Annals of Oncology • Mar 30, 2020

Authors:

M.C. Liu

Geoffrey R. Oxnard

Eric A. Klein

Abstract

BACKGROUND: Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to det...

Subject

Medicine

DNA methylation

Cell-free fetal DNA

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