Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

Shang, Anquan; Gu, Chenzheng; Zhou, Chen; Yang, Yibao; Chen, Chen; Zeng, Bingjie; Wu, Junlu; Lu, Wenying; Wang, Weiwei; Sun, Zujun; Li, Dong

doi:10.1186/s12964-020-0517-1

Public

Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

Published in Cell Communication and Signaling • Mar 30, 2020

Authors:

Anquan Shang

Chenzheng Gu

Chen Zhou

Abstract

Abstract Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. The current study aimed to elucidate the mechanism by which exosomes carrying KRAS mutant contribute to neutrophil recruitment as well as the formation of the neutrophil extracellular trap (NET) in...

Subject

Neutrophil extracellular traps

KRAS

Microvesicles

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