A multidimensional systems biology analysis of cellular senescence in aging and disease

A. Avelar, Roberto; Gómez Ortega, Javier; Tăcutu, Robi; J. Tyler, Eleanor; Bennett, Dominic; Binetti, Paolo; Budovsky, Arie; Chatsirisupachai, Kasit; Johnson, Emily; Murray, Alex; Shields, Samuel; Tejada-Martínez, Daniela; Thornton, Daniel; E. Fraifeld, Vadim; L. Bishop, Cleo; Pedro de Magalhães, João

doi:10.1186/s13059-020-01990-9

Public

A multidimensional systems biology analysis of cellular senescence in aging and disease

Published in Genome biology • Apr 7, 2020

Authors:

Roberto A. Avelar

Javier Gómez Ortega

Robi Tăcutu

Abstract

BACKGROUND: Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking. RESULTS:...

Subject

Biology

Senescence

Human genetics

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