NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

Zeng, Cheng; Duan, Fengqi; Hu, Jia; Luo, Bin; Huang, Binlong; Lou, Xiaoying; Sun, Xiuting; Li, Hongyu; Zhang, Xuanhong; Yin, Shengli; Tan, Hongmei

doi:10.1016/j.redox.2020.101523

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NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

Published in Redox Biology • Mar 30, 2020

Authors:

Cheng Zeng

Fengqi Duan

Jia Hu

Abstract

Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure, and the underlying mechanism remains largely elusive. Here we investigated whether NLRP3 inflammasome-mediated pyroptosis contributes to non-ischemic DCM and dissected the underlying mechanism. We found that hyper activa...

Subject

Pyroptosis

Inflammasome

Mitochondrial fission

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