A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

Hampel, Harald; Caraci, Filippo; Claudio Cuello, A.; Caruso, Giuseppe; Nisticò, Robert; Corbo, Massimo; Baldacci, Filippo; Toschi, Nicola; Garaci, Francesco; A. Chiesa, Patrizia; Verdooner, Steven; Akman-Anderson, Leyla; Hernández, Félix; Ávila, Jesús; Emanuele, Enzo; L. Valenzuela, Pedro; Lucía, Alejandro; Watling, Mark; P. Imbimbo, Bruno; Vergallo, Andrea; Lista, Simone

doi:10.3389/fimmu.2020.00456

Public

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

Published in Frontiers in Immunology • Mar 31, 2020

Authors:

Harald Hampel

Filippo Caraci

A. Claudio Cuello

Abstract

Neuroinflammation commences decades before Alzheimer’s disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout AD its continuum. Large-scale genome-wide association studies point out several genetic variants - TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, ...

Subject

Neuroinflammation

TREM2

Neurodegeneration

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